Slowing Progression of Knee Osteoarthritis

Grant number: 454686 | Funding period: 2007 - 2009

Completed

Abstract

Knee arthritis is a painful, disabling, costly condition particularly affecting the elderly. As there is presently no cure for arthritis, interventions that slow progression of the disease will reduce the personal and societal burden of arthritis. Recently it has been postulated that specific exercise that targets how the muscles are controlled by the nervous system may have greater disease-modifying effects than exercise aimed at strengthening the muscles. Data are beginning to highlight the complexity of muscle strategies adopted by the nervous system to compensate for joint derangement in knee arthritis. It is our contention that there may be specific strategies that provide more optimal ..

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Related publications (11)

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Saurab Sharma, Ross Wilson, Yana Pryymachenko, Anupa Pathak, Jason Chua, David Gwynne-Jones, Kim LL Bennell, Ben Metcalf, Rana SS Hinman, Michael AA Hunt, Boon-Whatt Lim, J Haxby Abbott

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OBJECTIVE: The Osteoarthritis Research Society International (OARSI) recommends assessment of physical function using a performanc..

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Increased duration of co-contraction of medial knee muscles is associated with greater progression of knee osteoarthritis

PW Hodges, W van den Hoorn, TV Wrigley, RS Hinman, KA Bowles, F Cicuttini, Y Wang, K Bennell

2016-02-01

Background: As knee osteoarthritis (OA) cannot be cured, treatments that slow structural disease progression are a priority. Knee ..

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Sagittal plane joint loading is related to knee flexion in osteoarthritic gait

MW Creaby, MA Hunt, RS Hinman, KL Bennell

2013-10-01

Background High mechanical loading has been consistently linked with medial tibiofemoral osteoarthritis, and is considered to play..

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Gait differs between unilateral and bilateral knee osteoarthritis

MW Creaby, KL Bennell, MA Hunt

2012-05-01

Objectives: To compare walking biomechanics in the most painful leg, and symmetry in biomechanics between legs, in individuals wit..

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Predicting dynamic knee joint load with clinical measures in people with medial knee osteoarthritis

MA Hunt, KL Bennell

2011-08-01

Knee joint loading, as measured by the knee adduction moment (KAM), has been implicated in the pathogenesis of knee osteoarthritis..

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Hip muscle weakness in individuals with medial knee osteoarthritis

RS Hinman, MA Hunt, MW Creaby, TV Wrigley, FJ McManus, KL Bennell

2010-08-01

Objective. To compare the strength of the hip musculature in people with symptomatic medial knee osteoarthritis (OA) with asymptom..

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Hip strengthening reduces symptoms but not knee load in people with medial knee osteoarthritis and varus malalignment: A randomised controlled trial

KL Bennell, MA Hunt, TV Wrigley, DJ Hunter, FJ McManus, PW Hodges, L Li, RS Hinman

2010-05-01

Objective: To determine whether hip abductor and adductor muscle strengthening reduces medial compartment knee load and improves s..

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Predictors of single-leg standing balance in individuals with medial knee osteoarthritis

MA Hunt, FJ Mcmanus, RS Hinman, KL Bennell

2010-04-01

Objective. To identify factors related to single-leg standing balance in individuals with medial compartment knee osteoarthritis (..

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Individuals with severe knee osteoarthritis (OA) exhibit altered proximal walking mechanics compared with individuals with less severe OA and those without knee pain

MA Hunt, TV Wrigley, RS Hinman, KL Bennell

2010-01-01

Objective. To examine hip, pelvis, and trunk walking biomechanics in individuals with medial compartment knee osteoarthritis (OA) ..

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Varus-valgus laxity and passive stiffness in medial knee osteoarthritis

MW Creaby, TV Wrigley, BW Lim, KA Bowles, BR Metcalf, RS Hinman, KL Bennell

2010-01-01

Objective. To compare differences in knee varus and valgus angular laxity and passive mechanical stiffness between asymptomatic kn..

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The effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: A protocol for a randomised, single-blind controlled trial

KL Bennell, MA Hunt, TV Wrigley, DJ Hunter, RS Hinman

2007-12-01

Background. Lower limb strengthening exercises are an important component of the treatment for knee osteoarthritis (OA). Strengthe..

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